Brian Kersey / Getty Images

Center fielder Michael Saunders #55 of the Seattle Mariners (R) collides with right fielder Eric Thames #10 as they go for a fly ball hit by Paul Konerko #14 of the Chicago White Sox during the ninth inning at U.S. Cellular Field on August 24, 2012 in Chicago, Illinois. The ball was dropped and Dewayne Wise #28 of the Chicago White Sox scored the winning run. The White Sox defeated the Mariners 9-8.  Continue reading the full story.

Orlin Wagner / AP

Kansas City Royals catcher Salvador Perez, right, dives to tag out Chicago White Sox's Orlando Hudson during the ninth inning of a baseball game in Kansas City, Mo., Friday, July 13, 2012.

Follow @msnbc_pictures

•Sign up for the msnbc.com Photos Newsletter

It was baseball's 21st perfect game and first since Philadelphia's Roy Halladay threw one against the Florida Marlins on May 29, 2010. It was the third in White Sox's history, joining Mark Buehrle against Tampa Bay on July 23, 2009, and Charles Robertson against Detroit on April 30, 1922.

With the White Sox lined up on the top step of the dugout, Humber fell behind 3-0 to Michael Saunders leading off the ninth. But he rebounded to strike him out. John Jaso then flied out before Brendan Ryan, another pinch-hitter, struck out to end the game.

-- Reported by the Associated Press

Elaine Thompson / AP

Chicago White Sox starting pitcher Philip Humber, center, is mobbed by teammates after pitching a perfect game against the Seattle Mariners, April 21, in Seattle. The White Sox won 4-0.

Related content: Slideshow of perfect games over the years

Follow @msnbc_pictures